In 1939, Bishop Byrne decided to alleviate the crowded conditions in St. Anne’s Parish by splitting off its southern section to create St. Vincent de Paul Parish. A 1.9-acre site was chosen on Bellaire (now Holcombe) Boulevard.
1941 - The first Pastor, Father Michael Leahy, dedicated the completed church and rectory in February 1941, but soon retired due to illness and was replaced by Father Dennis Connolly.
1943 – The original church building was completed and dedicated. The school was founded with four temporary classrooms and four teachers from the Congregation of the Incarnate Word and Blessed Sacrament.
1944 - A 3.5-acre tract behind the church was purchased and the school was expanded.
1948 - Intermediate classroom building was built
1949 - A Scout House was built by the men of the parish
1950 - Additional five acres along Buffalo Speedway was acquired for the current church site with the help of St. Jude and began the church's devotion to the saint
1953 - Current church built at corner of Buffalo Speedway and Holcombe and the first Mass celebrated on Christmas Day
1956 - Rectory built next to the church (current site of Our Lady of Lourdes Chapel)
1958 -Primary classroom building, gym and cafeteria were built. The former church became a parish activity center.
1973 - First lay Principal was appointed
1975 - Monsignor Dexter George became fourth Pastor
1981 - First School Board was elected
1985 - Monsignor Jamail became fifth Pastor
1992 - Middle school classroom building with library, administration and scout house were built. All parish buildings were renovated.
1996 – Monsignor Jamail Family Center was built
1998 - Gym's stage was renovated into a computer lab
2000 - Church gathering space added to expand seating
2002 - John Weyer became the sixth Pastor and established devotion to Diving Mercy
2004 - Middle school and library expansion
2006 - Carolyn Sears became Principal
2009 - Monsignor Bill became the seventh Pastor
2011 - Gym, cafeteria and interior of church were renovated
2017 - New rectory built
2019 - Our Lady of Lourdes chapel built on site of former rectory
2020 -Locker rooms renovated
2023 - New education building built; Jennifer Thompson Sen became Principal